the human cost of misinformation
July 23, 2022 3:56 AM Subscribe
Two decades of Alzheimer's research may be based on deliberate fraud that has cost millions of lives.
"Over the last two decades, Alzheimer’s drugs have been notable mostly for having a 99% failure rate in human trials. It’s not unusual for drugs that are effective in vitro and in animal models to turn out to be less than successful when used in humans, but Alzheimer’s has a record that makes the batting average in other areas look like Hall of Fame material.
And now we have a good idea of why. Because it looks like the original paper that established the amyloid plaque model as the foundation of Alzheimer’s research over the last 16 years might not just be wrong, but a deliberate fraud."
The article in Science.
"Over the last two decades, Alzheimer’s drugs have been notable mostly for having a 99% failure rate in human trials. It’s not unusual for drugs that are effective in vitro and in animal models to turn out to be less than successful when used in humans, but Alzheimer’s has a record that makes the batting average in other areas look like Hall of Fame material.
And now we have a good idea of why. Because it looks like the original paper that established the amyloid plaque model as the foundation of Alzheimer’s research over the last 16 years might not just be wrong, but a deliberate fraud."
The article in Science.
This post was deleted for the following reason: Um, I'm not going to make the obvious joke here, you're welcome. -- taz
Dupe
Oh weird, it didn't come up as having been posted before. I'll flag for deletion, thanks!
posted by fight or flight at 4:05 AM on July 23, 2022 [1 favorite]
Oh weird, it didn't come up as having been posted before. I'll flag for deletion, thanks!
posted by fight or flight at 4:05 AM on July 23, 2022 [1 favorite]
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posted by Bezbozhnik at 4:02 AM on July 23, 2022